CAR-T Therapy Discovery Service
An end-to-end In Vivo CAR-T Discovery platform designed to support developers from early target identification through preclinical evaluation and eventual CMC development.
Our integrated platform supports both viral and non-viral approaches to in vivo CAR-T development, enabling you to move from concept to IND-enabling studies through a single partner.
Accelerate Gene Therapy Development with End-to-End In Vivo CAR-T Discovery Services
Comprehensive Antibody Discovery Platform
Proven Experience
Optimized Delivery Approaches
Accelerate In Vivo CAR-T Development from Discovery to IND
Targeting Binder Available
SP34 is among the select few anti-CD3 antibodies with proven functional translatability and clinical validation, making it highly suited for vivo CAR-T applications. ProBio's ready-to-use SP34 Antibody Toolbox includes dozens of humanized SP34-derived variants with excellent thermal stability and diverse germline backgrounds. By leveraging these pre-optimized antibodiies, developers can bypass humanization efforts, shorten development timelines, and reduce the risk of affinity loss associated with generatingnew anti-CD3 binders from scratch
In addition, services include:
- Functional leads delivered in as little as 1 month
- Rapid, cost-efficient discovery with ProSpeed™ and Beacon®
- No subcloning required
- High-throughput hybridoma supernatant screening for rapid, reliable lead identification
- 300-donor alpaca naïve library (2 × 10¹¹ diversity)
- Direct alpaca farm access for rapid immunization
- Dedicated naïve alpaca per project
- Sourced from 2,000+ human donors
- Large library diversity (1.5 × 10¹¹)
- >98% insertion rate and sequence diversity; >90% in-frame rate
- High-affinity binders (10⁻⁸–10⁻¹⁰ M)
Lead Optimization Service
Antibody Humanization in as fast as 2.5 weeks,
Antibody Affinity Maturation - Guarantee 10 fold+ affinity improvement
Contact Us for Detailed Toolbox Information
Case Study
Accelerating CAR-T Antibody Discovery Using a Naïve VHH Library and Integrated Engineering Platform.
Resources
Brochure
One-stop CAR-T Discovery Solution
MODALITY
HUB
In Vivo CAR-T Modality Hub
FLYER
In Vivo CAR-T Discovery Service
WEBINARA
Innovative Approaches For CAR T Therapy From In Vitro to In Vivo
Frequently Asked Questions