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In vivo CAR-T Discovery
In Vivo CAR-T Discovery Service
CAR Lead and Targeting Binder Discovery
LVV/tLNP Packaging and Pharmacology Study
Integrated solution for In Vivo CAR-T Discovery
Expert in Antibody
Discovery
Discovery of CAR lead and targeting
binder
Ready-to-use targeting antibody
toolbox for rapid assembly and
functional testing
Targeting Binder
CAR Lead
Lead generation
Ready-to-used
Targeting Antibody
Toolbox
Ab humanization
Affinity maturation
Well-established
1 week
3-5 months
Pharmacology Platform
Cell-based in vitro transfection
In vivo study: PD/PK/Tox study
mRNA-tLNP packaging
LVV packaging
2-3 weeks
Truly One-Stop Partner
for In Vivo CAR-T
Development
In vitro functional assay
2-3 weeks
Antibody discovery
Pharmacology study
CMC for antibody, mRNA–tLNP
and tLVV
In vivo pharmacology
4-5 weeks
Expert in Antibody Discovery
Ready-to-Use Targeting
Antibody Toolbox
Well-suited Discovery Strategy
for CAR Leads
ProSpeedTM
PowerdomaTM
Hybridoma
Discovery
CD3 Antibody Toolbox:
Single B Cell
Screening
18 humanized sequences
derived from original SP34.
Good thermal stability and
sequence diversity with
different germlines.
Alpaca sdAb
Libraries
Human Fab
Naïve Library
Provide one-stop service from
packaging to pharmacology
validation
Test before payment
Antibody
Humanization
Antibody Affinity
Maturation
ProBioCDMO.com
+1-732-885-9188
Accelerating Ideas. Delivering Impact.
Well-established Pharmacology Platform:
In Vitro Functional Assay
Functional Assay for CAR Lead
Functional Assay for In Vivo CAR-T
CAR-T construction
LVV and tLNP packaging
Function assay for cytotoxicity and cytokine
release
Jurkat or PBMC based in vitro transfection
In Vivo Pharmacology Study
Milestone 1: Efficacy
Milestone 2:PK study
(Circulating & Infiltrated)
Milestone 3:Toxicity
(TGI, T/C, Survival)
(ex vivo & In vivo)
Anti-tumor efficacy
(syngeneic model, PBMC
model, HSC model etc.)
B cell depletion for
autoimmune diseases
In vivo candidates
In vitro & ex vivo on target
and off target delivery
In vivo transfection or
infectious efficiency
evaluation
CAR+ cell in vivo persistence
CAR+ cell infiltration
Early TCR study for CAR
binder characterization
Cytokine release
General toxicology in
rodent & NHP (hepatoxicity,
biochemistry etc.)
screening/dose-response
finding
Pathology
Truly One-Stop Partner for In Vivo CAR-T Development
One-Stop solution
One-Stop solution from
plasmid to mRNA-tLNP
from plasmid to LVV
4 months from sequence to IIT
9 months from sequence to IND
FAST IIT solution: 6months from
plasmid to mRNA-tLNP
IND-enabling CMC: 9 months from
plasmid to IND-ready mRNA-tLNP