RNA-tLNP One Stop Solution
Advanced RNA therapeutics development with ProBio's RNA-tLNP One-Stop Solution, offering mRNA manufacturing, targeted LNP delivery, GMP production, and global CDMO support.
IND-enabling CMC Services from Plasmid DNA to mRNA-LNP
mRNA Plasmid
The ProPlus™ linearized DNA manufacturing platform is designed to improve speed, cost efficiency, and product quality, reducing unit costs by 20% to 50%, accelerating turnaround times by up to 50%, and ensuring accurate poly(A) sequence control through CGE and Sanger sequencing.
IVT-mRNA/circRNA
ProBio offers comprehensive IVT-mRNA and IVT-circRNA manufacturing capabilities, featuring co-transcriptional and enzymatic capping with capping efficiencies exceeding 90%, crude IVT-mRNA yields of up to 10 g/L, and proprietary circRNA circularization technology that achieves up to 90% circularization efficiency with greater than 90% purity.
Antibody Development
Successfully delivered multiple types of antibody fragments (Fab, scFv, VHH)
Flexible GMP manufacturing scale — minimum batch size as low as 50L.
From Plasmid DNA to RNA-tLNP:
5 Months to IIT Materials
9 Months to GMP Materials & IND-enabling CMC
Antibody Conjugation Strategies for tLNP
Case Studies
Achieving >95% LNP-to-tLNP Modification Efficiency for Targeted RNA Delivery
RNA-tLNPs Enable Highly Specific T-Cell Targeting and Enhanced Gene Expression
Resources
WHITE
PAPER
Challenges and Solutions in the Poly(A) Control for Plasmid and mRNA
Learn about how consistent control strategies ensure poly(A) length and purity, from upstream plasmid to downstream production.
WHITE
PAPER
CircRNA White Paper
Learn about the 4 biggest barriers for circRNA manufacturing — Sequence design, circularization efficiency, impurity control, scalable production.
WEBINAR
mRNA & CircRNA-tLNP Webinar
Learn how RNA therapeutics and targeted lipid nanoparticles (tLNP) are opening new possibilities for engineering CAR-T cells directly in the body.
FLYER
Manufacturing Plasmids for mRNA Vaccines
Learn about an integrated and accelerated one-stop CDMO solution for IND filing: design, manufacturing, and downstream application for mRNA vaccines.
Frequently Asked Questions