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ProBio Antibody Humanization Service – fast, high-success humanization banner with no affinity loss guarantee

Antibody Humanization Service

A fast, integrated, and low-risk pathway to clinically viable antibody candidates, combining speed, guaranteed affinity retention, and early developability de-risking.
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Case Studies
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Fast Antibody Humanization with No Affinity Loss

Fast Turnaround

• As fast as 2.5 weeks
• Tailored to your project needs

Guaranteed Affinity Retention

• No loss of affinity
• >95% humanization rate
• 700+ projects delivered

Developability by Design

• Early developability risk assessment
• Optimize for manufacturability

Antibody Humanization with Integrated Developability Optimization

Antibody humanization service workflow Chimeric antibody characterization and humanization design with PTM analysis lead to back-mutation library development and high-throughput screening, followed by humanized antibody production and purification. Express service provides affinity validation in 2.5 weeks. Deluxe service includes developability prediction and comprehensive validation in 11 weeks. Design &Analysis in 2 days ChimericAntibody (Ab)Characterization HumanizationDesign & PTMAnalysis ~10³ clones Back–MutationLibrary High–ThroughputScreening Up to 9 Abs Humanized AbProduction &Purification AffinityValidation DevelopabilityPrediction ComprehensiveValidation Express 2.5 weeks Deluxe 11 weeks

Whether you are working with monoclonal antibodies, scFvs, or nanobody formats, ProBio delivers reliable, rapid, and scalable antibody humanization solutions.

Express Service Package

Rapid antibody humanization using proven CDR grafting and back-mutation strategies to preserve affinity.

•As fast as 2.5 weeks
•Guaranteed affinity retention
•Guaranteed at least 1 lead antibody with comparable affinity to the parental antibody

Deluxe Service Package

Identify optimized antibody candidates through library-based high-throughput (HTP) screening, early developability assessment, and comprehensive validation.

•Screen up to 1,000 variants in 11 weeks
•Identify and mitigate developability risks early
•Guaranteed at least 3 lead antibodies with comparable affinity to the parental antibody

Case Studies

ProBio Antibody Humanization Case Study – maintaining affinity and binding performance through antibody humanization

Maintaining Affinity and Binding Performance

Through Antibody Humanization

 

ProBio VHH Humanization Case Study – retaining high-affinity binding analyzed by Biacore for nanobody therapeutic development

VHH Humanization: Retaining High-

Affinity Binding (Biacore Analysis)

 

Resources

ProBio Discovery of Functional Antibody Leads – article on obtaining more functional leads at early stage of lead screening

HAND

BOOK

Discovery of Functional Antibody Leads at Early Stage of Lead Screening

Solutions to obtain more functional leads at an earlier stage.
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ProBio Discovery of Functional Antibody Leads – article on obtaining more functional leads at early stage of lead screening

BROCHURE

Biologics Discovery Services Brochure

Tailored discovery strategies for diverse biologics modalities, designed to enhance success rates.
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ProBio Antibody Lead Optimization Service Brochure – accelerating antibody candidates with comprehensive optimization services

HAND

BOOK

Antibody Lead Optimization Service

Learn more about how to accelerate antibody candidates with our lead optimization services.
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ProBio Antibody Engineering and Developability White Paper – integrated antibody engineering and developability assessment platforms

WEBINAR

Antibody Engineering and Developability Service

This webinar covers integrated antibody engineering and developability assessment platforms by ProBio to expedite the drug discovery process.
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Get Humanized Antibodies in as Fast As 2.5 Weeks.
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Frequently Asked Questions