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ProBio Antibody Humanization Service – fast, high-success humanization banner with no affinity loss guarantee

Antibody Humanization Service

A fast, integrated, and low-risk pathway to clinically viable antibody candidates, combining speed, guaranteed affinity retention, and early developability de-risking.
Overview
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Case Studies
Related Services
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Fast Antibody Humanization with No Affinity Loss

Fast and Flexible

From sequence to humanized candidate in 2.5 weeks, approaches tailored around you.

Quality We Guarantee

Humanization without compromise on efficacy, no loss of affinity and a humanization rate of >95%.

Proven Experience

A trusted platform with proven clinical translation, with 700 humanization projects delivered.

Antibody Humanization Services for Fast, Low-Risk Therapeutic Development

Antibody humanization service workflow A branched timeline comparing Express Service and Deluxe Service for antibody humanization, from design and developability prediction through production, screening, measurement and characterization. Design and analysis in 2 days Ab humanization design Developability prediction (PTM, Immunogenicity, Aggregation) Ab production and purification (Chimeric /humanized Ab) Back mutation library construction and FASEBA screening SPR, thermal stability screening, PTM removal Ab affinity measurement and sequence confirmation Ab production and characterization Express Service 2.5 weeks Deluxe Service 11 weeks

Whether you are working with monoclonal antibodies, scFvs, or nanobody formats, ProBio delivers reliable, rapid, and scalable antibody humanization solutions.

Express Service Package

Our Express Package utilizes CDR grafting and back mutation

technologies to generate humanized antibodies with high expression

levels and good thermal stability.

•As fast as 2.5 weeks to get your antibody humanized
•Guarantee at least 1 antibody with affinity comparable to parent antibody

Deluxe Service Package

The Deluxe Package combines mutation library construction, FASEBA

HTP screening technology to identify the optimal variants, with

synthesis, recombinant expression, and affinity validation of the top 3 leads.

•Get Humanized Antibody with highest degree of humanization in 11 weeks
•Guarantee at least 3 antibodies with affinity comparable to parent antibody

Case Studies

ProBio Antibody Humanization Case Study – maintaining affinity and binding performance through antibody humanization

Maintaining Affinity and Binding Performance

Through Antibody Humanization

 

ProBio VHH Humanization Case Study – retaining high-affinity binding analyzed by Biacore for nanobody therapeutic development

VHH Humanization: Retaining High-

Affinity Binding (Biacore Analysis)

 

Resources

ProBio Discovery of Functional Antibody Leads – article on obtaining more functional leads at early stage of lead screening

HAND

BOOK

Discovery of Functional Antibody Leads at Early Stage of Lead Screening

Solutions to obtain more functional leads at an earlier stage.
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ProBio Discovery of Functional Antibody Leads – article on obtaining more functional leads at early stage of lead screening

BROCHURE

Biologics Discovery Services Brochure

Tailored discovery strategies for diverse biologics modalities, designed to enhance success rates.
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ProBio Antibody Lead Optimization Service Brochure – accelerating antibody candidates with comprehensive optimization services

HAND

BOOK

Antibody Lead Optimization Service

Learn more about how to accelerate antibody candidates with our lead optimization services.
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ProBio Antibody Engineering and Developability White Paper – integrated antibody engineering and developability assessment platforms

WEBINAR

Antibody Engineering and Developability Service

This webinar covers integrated antibody engineering and developability assessment platforms by ProBio to expedite the drug discovery process.
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Get Humanized Antibodies in as Fast As 2.5 Weeks.
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