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200+ tumor cell line panels
6 type tumor animal models
In vivo efficacy is the gold standard for evaluating biological activity of drugs, and it is the first time comprehensive activity validation before clinical studies. In vivo efficacy evaluation plays a critical role in candidates identification and clinical target indications screening, which is an indispensable step during the process of drug development. ProBio has established 6 oncology animal models following international high standards. Besides, we can provide various diseases of In vivo models including inflammation, autoimmunity, metabolic diseases and customized services to meet different needs from customers.
200+ tumor cells to meet diversified needs
Model features:
✔ Easy to handle, high tumorigenesis
✔ Low cost, more cost-effective
✔ Short experimental time, suitable for early screening
A. Tumor growth curve and body weight for Pan02 xenograft model
B. Test antibody inhibit MC38 growth in vivo
✔ Immunodeficient mouse, efficacy focus on tumor itself
✔ Human cancer cell line
✔ Flexible, easy to handle, widely used
A. In vivo LC1sq, NCI-H2291, NCH-1581 NSCLC cancer cell line growth curves
✔ Humanized Immune system in immunodeficient mouse, TME more similar to human
✔ Humanization can be conducted by Human PBMC or HSC
✔ Hard to handle
A. A549 in vivo growth curves (Human PBMC humanized NSG mice)
Model Features:
✔ Immunocompetent system
✔ Suitable for No-species-cross-reactivity antibodies
✔ Target humanized mice and tumor cell lines should be prepared in advance
A. In vivo anti-tumor activity of Keytruda and Opdivo in hPD1 mice
Orthotropic and metastasis tumor model can better manifest human tumor environment, keep original biological characteristics, and more relevant with clinical. ProBio can provide a variety of orthotropic or metastasis tumor models to meet different needs from customers.
Lung Orthotropic A549 tumor
Lung Metastasis A549 tumor
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