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In Vivo Pharmacology
In Vivo Pharmacology
Discovery to development include PD/PK/Tox
Integrated biopharmaceuticals discovery and CMC production
ProBio’s in vivo pharmacology R.&D. service platform provides a range of services for
various types of drugs. These services include in vivo PD, PK, toxicology studies, and
biological sample analysis. Combining one-stop project management, our platform
meets the compliance requirements for new drug applications, enabling faster, better,
and more cost-effective.
Business License
MOA Design
IND Filing
Drug Candidate
Application
Lead Generation &
CMC Production &
Optimization
in vivo pharmacology
Drug Discovery
Drug Development
Clinical Trials
IIT / IIR & IST
Preclinical supplementary research
Extended indications research
Animal Model Development
In vivo early PD
In vivo early PK
In vivo biological activity
In vivo PD
In vivo PK
In vivo early toxicity
In vivo toxicity
Key Features
Available for various
One-stop platform
Extensive R&D experience
drug modalities
In vivo efficacy & DMPK studies
Safety evaluation (Early stage & GLP)
Diverse bioanalytical detection
Integrate high-quality resources
（CMC+ Ecology, GMP+GLP）
Customized services
Monoclonal antibodies（mAb）
Bispecific antibodies（bsAb）
Antibody drug conjugates(ADCs)
Cell and gene therapy（CGT）
Recombinant or fusion Proteins
Vaccines
200+ PD/PK/ex-vivo drug discovery
70+ CGT discovery
35+ PD/PK/Tox one-stop integrated
projects
15+ global IND approvals
Expertise in meeting regulatory
requirements of NMPA/FDA/EMA
ProBioCDMO.com
+1-732-885-9188
Accelerating Ideas. Delivering Impact.
In Vivo Efficacy and Biological Activity Study
Antitumor mouse models
Non-tumor disease models
Syngeneic model
Metabolic disease models
Autoimmune disease models
In vivo bioactivity assay
Transgenic model
CDX model
PBMC immune humanization model
Metastasis or orthotopic model
Assisted reproductive drug efficacy
Regenerative treatment
Customized services
In Vivo DMPK & Bioanalysis
Bioanalysis
In Vivo DMPK
Plasma stability
Tumor Infiltrating Lymphocytes
Pathological
Method development and validation
PK or PK-PD test
Tissue Cross-Reactivity
Immuno-phenotyping
Cytokine testing
ADA & Nabs test
Tissue distribution
Receptor occupancy
Tissue chip
Customized services
In Vivo Toxicity
Early Toxicity (Non-GLP)
GLP Toxicity
Drug tolerance
Acute toxicity
Animal survival rate
Predict toxic effects
Other customized services
Long-term toxicity
Safety pharmacology
Tissue cross reactivity
Preparation safety
Immunotoxicity
Genotoxicity
Reproductive toxicity