White Paper
How to Design and Evaluate BsAbs
- What are BsAbs?
- How to design discovery strategies based on structure?
- How to evaluate BsAbs comprehensively by MOA?
Molecule Focus: Bispecific Antibody (BsAb)
xplore All BsAb Resources in One Convenient Hub
Molecule Focus: Bispecific Antibody (BsAb)
Compared to monoclonal antibodies (mAbs), BsAbs have stronger therapeutic potential. BsAbs' novel MOAs offer improved efficacy and safety, with clinical results supporting their use in cancer treatment. Discover a curated collection of expert resources to support every stage of your BsAb development. Register Once to Unlock All Resources.
Start Strong with BsAb Discovery
BsAbs operate through diverse MOAs, including cell engager, dual-target blockade, dual immunomodulators, and cell surface protein bridging. Choosing the right targets and MOAs is key to discovery success.
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Reliable Cell Line Development
Successful manufacturing of BsAbs requires precise assembly of multiple polypeptide chains. Improper pairing of heavy and light chains can lead to non-functional or monospecific by-products.
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Poster
Optimized Vector System for BsAb Expression in CHO-K1 Cells
White Paper
Cell Line Development Strategies for BsAb Manufacturing
Accelerated CMC Development
BsAb process development meets multiple challenges such as product expression, homodimer & aggregation control, N-glycan optimization. Explore how to overcome these obstacles while accelerating timeline and implementing robust analytical strategies
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Folding
From Sequence to Tox DS Release in 7 Months for Symmetrical BsAb
White Paper
Analytical Approach for BsAb Quality Study
Smooth Tech Transfer and Qualified Manufacturing
Ensure a smooth and efficient transition from process development to GMP manufacturing—customized to your scale and regulatory needs
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Handbook
Tech Transfer Manual
Folding
GMP Manufacturing Solutions
Proven Success
By providing a comprehensive suite of CMC development and IND dossier services, ProBio supported IMBiologics in obtaining FDA clearance and achieving a smooth license-out.
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News
2023 ProBio Congratulates IMBiologics on FDA Clearance of IND Application for Innovative Bispecific Antibody Drug Project (IMB-101)
On-demand Webinar
Expand your knowledge with expert-led webinars focused on BsAb discovery, development, and regulatory solutions
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Webinar
Multiple Solutions of Functional Leads Discovery and Engineering
Webinar
ProBox™ Platform for Complex Biologics CMC Development
Webinar
Navigating Biologics Challenges：Regulatory, Process Development, and Tech Transfer Solutions
