Linearized DNA CMC to GMP
Linearized plasmid DNA manufacturing services designed to support the production of mRNA vaccines and therapeutics from preclinical development through commercial GMP supply.
Phase Appropriate Plasmid Preparation Support
Proven Experience
With a proven track record of supporting plasmid IND clearances and IIT programs, ProBio delivers flexible manufacturing solutions tailored to diverse project requirements and timelines, helping accelerate development from early-stage research to clinical advancement.
Advancing Programs
ProBio accelerates your journey from IND to clinical trials with phase-appropriate manufacturing services, proprietary technologies, and rapid turnaround times.
Commercial Readiness
ProBio provides comprehensive commercial manufacturing solutions for process characterization (PC) and process validation (PV), fully aligned with Biologics License Application (BLA) requirements.
Proprietary Technology to Guarantee Poly(A) Purity
Case Studies
Enhancing Long Poly(A) Plasmid Stability with ProBio's Proprietary PowerS™ Strain and Backbone
Resources
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Challenges and Solutions in the Poly(A) Control
Learn more about control strategies to ensure consistent poly(A) length and purity, from upstream plasmid synthesis to downstream production.
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Cell-Free Plasmid Linearization At Speed Through ProSyn™
Discover scalable, high purity linearized DNA with ProSyn™ platform, leveraging rolling circle amplification and an optimized cell-free enzymatic DNA synthesis platform.
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Linearized DNA Manufacturing
Read how linearized DNA manufacturing is optimized through various processes, from traditional E. coli fermentation-based to cell-free platforms.
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Manufacturing Plasmids for mRNA Vaccines
Learn about an integrated and accelerated one-stop CDMO solution for IND filing: design, manufacturing, and downstream application for mRNA vaccines.
Frequently Asked Questions