Antibody Discovery Solution for Multi-Pass Membrane Targets
A specialized antibody discovery platform for multi-pass membrane protein targets, including
highly challenging target classes. Accelerate the discovery of functional, developable
antibody candidates against complex membrane proteins that are traditionally difficult to target.
Multi-Transmembrane Target Antibody Discovery Services
Innovative Solutions
Proprietary mRNA and VLP immunization strategies and Powerdoma™ platform to address complex antigen preparation and find functional leads faster.
Comprehensive Pharmacology Platform
Access to 150+ GPCR functional cell lines and multiple assay formats to address complex GPCR biology.
Proven Track Record
More than 480 completed projects with specialized experience in multi-pass membrane target projects (over 20) and 5 delivered pipelines moving into clinical phases.
Advanced Antibody Discovery Solutions for Complex Membrane Proteins
Immunization
Cell fusion
High throughput ELISA/FACS screening
High throughput functional screening
Antibody production
In vitro bioassay
Unique immunization strategies including: protein, peptide, cell line, DNA and mRNA, VLP immunization.
Powerdoma™ hybridoma discovery platform:
- Eliminates subcloning steps, obtaining positive binders in 2 weeks.
- High-throughput screening using hybridoma supernatant, ensuring screening sensitivity and accuracy.
- Over 150 GPCR functional cell lines at our disposal.
- 4 assays including calcium flux , cAMP and luciferase.
- Versatile MOAs - agonist, antagonist, allosteric modulation.
- Over 150 GPCR functional cell lines.
- One-stop in vivo pharmacology study: PD/PK/Tox.
Case Study
Rapid Discovery of Functional Anti-CCR8 Antibodies Using ProBio's DNA/mRNA Hybridoma Platform
Resources
BROCHURE
Biologics Discovery Services Brochure
Tailored discovery strategies for diverse biologics modalities, designed to enhance success rates.
FLYER
Powerdoma™ Hybridoma Discovery Service
Accelerate your discovery timelines by enabling faster functional screening at earlier stages.
WHITE
PAPER
Discovery of Functional Antibody Leads at Early Stage of Lead Screening
Solutions for antibody discovery platforms to overcome the limitations and improve efficiency of lead discovery.
POSTER
Powerdoma™: An Upgraded Hybridoma Platform
Fast timelines and improved cost-effectiveness for antibody discovery.
Frequently Asked Questions