LentiHelper™ Plasmids
ProBio's LentiHelper™ plasmids enable streamlined lentiviral vector production from preclinical development to commercial manufacturing. Available in PreCMC, GMPro™, and GMP grades, these FDA DMF-registered helper plasmids are manufactured on a regulatory-compliant platform and offer a royalty-free, IP-friendly solution for scalable gene therapy development.
LentiHelper™ Packaging Plasmids for Cell & Gene Therapy Development
Proprietary Packaging System
3 ready-to-use helper plasmids and LentiBone™ backbone for LVV transfer plasmid available, to reduce costly IP and royalty issues.
Regulatory Compliance
Our helper plasmids are DMF registered and ready for FDA IND applications, ensuring minimal timeline delays.
Manufacturing Consistency
Manufactured using de novo synthesis, we provide multiple grades to support progression from preclinical through GMP.
GMP-Ready Helper Plasmids for Scalable LVV Manufacturing
3ʳᵈ Generation Lentiviral Vector Packaging System
LentiBone™GOI: gene of interest
Transfer Plasmid
LentiHelper™ VSV-GLentiHelper™ RevLentiHelper™ GagPol
PowerA™-293T
PowerS™-293T
Cell Line
Lentiviral Vector
Case Studies
~2.6 times LVV titer by using LentiHelper™ plasmid, compared to the competitor's
Resources
WHITE
PAPER
Challenges and Solutions in the Poly(A) Control for Plasmid & mRNA
Learn about how consistent control strategies ensure poly(A) length and purity, from upstream plasmid to downstream production.
FLYER
Cell Therapy: 6-month One-Stop Solution for IND Filing
Discover an integrated solution from plasmid to LVV, at high quality and speed.
FLYER
GMP Plasmid Manufacturing
Whether you’re working on a gene therapy, cell therapy, DNA vaccine or mRNA vaccine, it starts with high-quality DNA.
WHITE
PAPER
Design of Targeting Lentiviral Vectors and Their Producer Cells for in Vivo CAR-T
Learn about successful LVV design, manufacturing, and downstream application for in vivo CAR-T.
