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One Stop Solution for Cell Therapy IND Filing – in as little as 6 months
Cell Therapy
6-Month One-stop Solution for IND Filing
Partner with ProBio to Achieve the Next Milestone
3rd Generation Lentiviral Vector System
LVV Plasmid Platform
Global supply: both CN and US
plasmid facility
Licensed strain is clear sourced
without IP issue
LentiHelperTM
VSV-G
LentiHelperTM
Rev
LentiHelperTM
GagPol
Transfer
Plasmid
Ready-to-useLentiHelperTM plasmids
with FDA DMF Registration
(MF25552)
LentiBone
Viral Vector Packaging
Cell Therapy
Licensed adherent cell line:
PowerATM-293T with CDMO authority
Proprietary suspension cell line:
PowerSTM -293Twith FDA DMF
registration (MF29374/0)
Lentiviral vector with GOI
Solid Track Records with over 90 Global IND Approvals
Proven Solution with 900+ Clinical Manufacturing batches
Phase
Phase
Phase
IND
BLA
I
II
III
Commercial
GMP Grade
GMP Grade
PreC
M
C
G
ra
de
IND CMC
GMP-Principle* Grade
GMP Grade
BLA PC/PV
BLA PC/PV
Plasmid
Lentiviral
Vector
P
r
o
G
r
a
d
e
IND CMC
Clinical GMPGrade
GMP Grade
*2 choices in GMP-Principle grade: IND Pro for FDA & EMA; GMProTM for NMPA(China), FDA & EMA
ProBioCDMO.com
+1-732-885-9188
Accelerating Ideas. Delivering Impact.
6-Month One-stop Solution from Plasmid to Lentiviral Vector
2
4
6
8
10
12
Month
Traditional Timeline
ProBio Timeline
Plasmid: Accelerate Your Breakthrough with The Timelines You
Need and The Quantities You Can Count On
High Density Fermentation: up to 1g/L
95% supercoiled plasmid
Fermentation time (h)
Yield (mg/L) OD600 Unit Yield (mg/L/OD)
LVV: High Titer and Yield
Stable and High Yield (1E7~1E8 TU/ml)
LVV produced by PowerSTM-293T cell line shows
higher titer than other cell lines
6.00E+07
5.00E+07
4.00E+07
3.00E+07
2.00E+07
1.00E+07
0.00E+00
7
2.0×10
7
1.5×10
7
1.0×10
6
5.0×10
0
2L Scale
50L Scale
PowerS-293T
Competitor-O Cell line