Rapid and stable cell line development in just 10 Weeks from DNA to Top 6 Clones.
Overview
Workflow
Case Studies
Related Services
FAQs
Accelerate Your Project from Research to Clinic
Industry Leading Timelines
As fast as 10 weeks from gene synthesis to Top 6 clones and 14 weeks to Top 1 clone.
Proven Performance
With demonstrated average antibody titers of 7.5g/L, mAb max. titer 15g/L and 60-90 generation stability study.
Complex Molecule Experience
With demonstrated average titer 7.0 g/L, up to 10 g/L in bsAb and 5.8 g/L, up to 14.5 g/L in protein.
High-Yield Cell Lines, Built for the Clinic
Cell Pool Development
7 weeks
Developability assessment
Late discovery stage, after humanized candidates
Cell Line Development
10 weeks
6 PCBs
Preclinical CMC development
Cell Line Development and Clone Evaluation
14 weeks
Top 1 clone
Feed and medium selection
Ambr15 bioreactor performance evaluation
Case Studies
This case study demonstrates the performance of ProBio's proprietary CHOK1-ADCC+ cell line, which was developed specifically to produce afucosylated antibodies with enhanced ADCC
This case demonstrates how ProBio’s platform supports accelerated and high yield development to propel faster CMC in mAb and bsAb development.
Resources
HAND
BOOK
Cell Line Development Solutions for Biomanufacturing
Break through to next level of productivity with our integrated solutions.
WHITE
PAPER
Optimized Cell Line Development
Strategies for Bispecific Antibody Manufacturing.
hand
book
How to Design and Evaluate Bispecific Antibodies(BsAbs)?
Develop bsAbs discovery strategies based on structure.
POSTER
ProGram Fast
Gram Level Fast Sample Preparation, 1 Gram mAb Delivered in 5 weeks.
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