Single-Domain Antibody (sdAb) Discovery Service
Three tailored single-domain antibody discovery workflows to support successful development and accelerate your research speed from target to preclinical candidate molecules in various modalities.
More functional sdAb binders with higher sequence diversity in as fast as 9 weeks.
Accelerate Your Research from Target to PCC
Established Track Record
Over 350+ completed sdAb lead generation projects, including an FDA-approved drug.
Demonstrated Success in Strategic Partnerships
Over 9 global licensing deals in place with Biopharma organizations.
Validated Success in sdAb Humanization
Over 160 humanization progress with a 96% success rate.
Customize Your Solution with Three Discovery Approaches
Discovery
Screening
In Vitro
Functional Assay
Screening
sdAb
Humanization
sdAb Affinity
Maturation
In Vivo
Pharmacology
Developability
Assessment
Beacon®-based sdAb discovery
Overcome the limitations of traditional library screening by integrating alpaca single‑B‑cell isolation, high‑throughput Beacon® screening, and ProSpeed™ rapid expression.
This streamlined workflow preserves sequence diversity and delivers a higher number of functional sdAb in as fast as 9 weeks.
This streamlined workflow preserves sequence diversity and delivers a higher number of functional sdAb in as fast as 9 weeks.
9 weeks
From immunization to functional leads
Alpaca Immunized Library
We combine our high-quality libraries with customized phage display panning strategies and our proprietary SPSSdAb™ screening platform to help you discover high-potential single domain antibody leads, faster.
Our Alpaca Immunized Library provides access to immunization-ready alpacas, using only naïve alpacas for each project, for a clean and targeted immune response.
Our Alpaca Immunized Library provides access to immunization-ready alpacas, using only naïve alpacas for each project, for a clean and targeted immune response.
12 – 16 weeks
From immunization to functional leads
Alpaca Naïve Library
Our Alpaca Naïve Library is derived from 300 alpaca donors with a 2x1011 library size.
The SPSSdAb™ platform utilizes both phage and soluble antibody formats to enable direct ELISA, FACS, and SPR analysis from expression supernatants. For early HTP SPR ranking and increasing potential identification of high‑affinity sdAbs.
The SPSSdAb™ platform utilizes both phage and soluble antibody formats to enable direct ELISA, FACS, and SPR analysis from expression supernatants. For early HTP SPR ranking and increasing potential identification of high‑affinity sdAbs.
5 - 6 weeks
From immunization to functional leads
Case Studies
Rapid Discovery of High-Affinity CD3 VHH Antibodies Using an Integrated sdAb Platform
Accelerating CAR-T Antibody Discovery Using a Naïve VHH Library and Integrated Engineering Platform
Resources
ARTICLE
Small and Mighty: Single-Domain Antibodies Pack a Biological Punch
What are VHH antibodies and why does their structure make them unique?
WEBINAR
Integrated sdAb Discovery via Phage Library and Single B Cell Screening
How phage display and single B-cell technologies can be utilized for sdAb lead generation
WHITE
PAPER
Discovery of Functional Antibody Leads at Early Stage of Lead Screening
Solutions for antibody discovery platforms to overcome the limitations and improve efficiency of lead discovery.
BROCHURE
Biologics Discovery Services Brochure
Tailored discovery strategies for diverse biologics modalities, designed to enhance success rates.
Frequently Asked Questions