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Accelerate Your Path to IND with ExpressCMC
Fast-Track DNA to IND Service
DNA to Tox Batch Ready in 4 Months
DNA to GMP DP Release in 9 Months
ProBio offers a truly integrated CMC platform that transforms DNA sequences into GMP
clinical drug product with unmatched speed, productivity and reliability. Purpose-built for
monoclonal and symmetric bispecific antibodies, our ExpressCMC enables Tox DS production
completion in as early as 4 months and GMP drug product release in just 9 months. This
ultra-rapid timeline is driven by the application of the proprietary ProMax vector, which is
high-yield and exceptionally stable, enabling the earliest possible identification of top clones
and an early start of Tox batch manufacturing.
Tox DS (PCB) ready
Service Highlights
Tox Material Batch in
4 Months
GMP DP in 9 Months
High Titer,
Long-term Stability
Quickly advance to critical
preclinical toxicology
evaluation, saving significant
development time.
Enable faster transition to
clinical trials and secure
a competitive edge in
the race to market.
Proprietary ProMax
vector provides a solid
foundation for your drug
development success.
ProBioCDMO.com
+1-732-885-9188
Accelerating Ideas. Delivering Impact.
Achieve High Titer and Exceptional Stability
with ProMax Vector
TiterLift™ titer boosting element
Significantly High Titer
The TiterLift™ element enables superior integration
ProMax
efficiency, rapidly generating clones with high transgene
copy numbers, which directly boost initial titer (~6g/L mAb,
~9g/L bispecific Ab).
SteadyHold™ stability enhancing element
Exceptional Long-Term Stability
The SteadyHold™ element sustains transgene expression activity, preventing the transgene
from being switched off over time, resulting in minimal titer drop (<30%) over 60+ generations
without selective pressure.
ProMax vectors demonstrated stability in all tested clones, with a titer drop of
<30% in stability studies over 60+ generations without selective pressure.
BSAB2 clone stability
MAB2 clone stability
MAB1 clone stability
PDL0
PDL60
PDL0
8
6
4
2
0
6
4
2
0
10
PDL0
PDL0
PDL0 PDL60
PDL60
PDL60
PDL60
PDL0
PDL0
PDL60
PDL0
PDL60
8
PDL60
PDL0
PDL60
6
4
2
0
clone98
clone290
clone335
Clone84
Clone95
Clone311
Clone30
Clone183
Clone223