Molecule Focus: Bispecific Antibody (BsAb)

Lead Discovery, Cell Line Development, CMC, Tech Transfer, Manufacturing, Regulatory

Compared to monoclonal antibodies (mAbs), BsAbs have stronger therapeutic potential. BsAbs' novel MOAs offer improved efficacy and safety, with clinical results supporting their use in cancer treatment. Discover a curated collection of expert resources to support every stage of your BsAb development. Register Once to Unlock All Resources.

1. Start Strong with BsAb Discovery

BsAbs operate through diverse MOAs, including cell engager, dual-target blockade, dual immunomodulators, and cell surface protein bridging. Choosing the right targets and MOAs is key to discovery success.

White Paper: How to Design and Evaluate BsAbs

  • What are BsAbs?

  • How to design discovery strategies based on structure?

  • How to evaluate BsAbs comprehensively by MOA?

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Start Strong with BsAb Discovery

White paper: How to Design and Evaluate BsAb

2. Reliable Cell Line Development

Successful manufacturing of BsAbs requires precise assembly of multiple polypeptide chains. Improper pairing of heavy and light chains can lead to non-functional or monospecific by-products.

Poster: Optimized Vector System for BsAb Expression in CHO-K1 Cells

White Paper: Cell Line Development Strategies for BsAb Manufacturing

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3. Accelerated CMC Development

BsAb process development meets multiple challenges such as product expression, homodimer & aggregation control, N-glycan optimization. Explore how to overcome these obstacles while accelerating timeline and implementing robust analytical strategies

Folding: From Sequence to Tox DS Release in 7 Months for Symmetrical BsAb

White paper: Analytical Approach for BsAb Quality Study

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4. Smooth Tech Transfer and Qualified Manufacturing

Ensure a smooth and efficient transition from process development to GMP manufacturing—customized to your scale and regulatory needs

Handbook: Tech Transfer Manual

Folding: GMP Manufacturing Solutions

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5. Proven Success

By providing a comprehensive suite of CMC development and IND dossier services, ProBio supported IMBiologics in obtaining FDA clearance and achieving a smooth license-out.

2023 ProBio Congratulates IMBiologics on FDA Clearance of IND Application for Innovative Bispecific Antibody Drug Project (IMB-101)

2024 IMBiologics Licenses $925mn Antibody Treatment (IMB-101) to Navigator Medicines

mRNA CDMO
LVV/AAV CDMO

Proven track records with

80+

BsAb discovery projects

14

BsAb IND clearances

6. On-demand Webinar

Expand your knowledge with expert-led webinars focused on BsAb discovery, development, and regulatory solutions

Multiple Solutions of Functional Leads Discovery and Engineering

ProBox™ Platform for Complex Biologics CMC Development

Navigating Biologics Challenges：Regulatory, Process Development, and Tech Transfer Solutions

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