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cGMP AAV manufacturing and production services - ProBio CDMO

AAV GMP Manufacturing

Scalable, reliable AAV manufacturing platform, delivering high-quality vectors from preclinical research through GMP clinical production.

Speed and Precision with PowerS™-293 in AAV Manufacturing Workflow

AAV GMP Manufacturing workflow Three plasmids are co-transfected into a proprietary PowerS–293 suspension cell line to produce AAV vectors. pAAV–vector pAAV–helper pAV–helper promivsTransgenepA RepCap E4E2aVA pAAVpHelperpAV Co–transfection of 3 plasmids: AAssistV™–pHelper+ AAssistV™–pRC + Transfer plasmid Proprietary PowerS™–293suspension cell line with FDA DMFregistration AAV Vector

AAV Vector Service Overview

AAV GMP Manufacturing workflow AAV development timeline from Preclinical through Commercial, followed by manufacturing grades and a comparison of Pro AAV and Clinical GMP AAV deliverables. PreclinicalINDPhase I Phase IIPhase IIIBLACommercial Pro GradeIND CMCClinical GMP Grade GMP GradeBLA CMCGMP Grade Pro AAVClinical GMP AAV Cell ExpansionTransfectionHarvest PurificationFill and FinishQC Release Manufacturing Summary ReportCOA/ROATSE/BSE Statement Controlled Manufacturing EnvironmentSegregated Manufacturing Suites
Case study: PowerS™-293 cell population uniformity enhances AAV process consistency
Case study: PowerS™-293 cell line outperforms competitors in AAV manufacturing
Resource flyer: GMP AAV plasmid manufacturing - ProBio
Resource poster: AAV manufacturing with PowerS™-293 suspension cell line
Resource flyer: GMP viral vector manufacturing for clinical and commercial use
Resource poster: PowerS™-ITRrs strain for AAV transfer plasmids
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