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Manufacturing Process from Plasmid to mRNA

Cell banking
High density fermentation
Harvest
Lysis
Purification
Test and release
Enzyme digestion
Chromatographic purification
Test and release
IVT-mRNA
In vitro transcription
Chromatographic purification
UF/DF
mRNA DS
mRNA-LNP
mRNA encapsulation
UF/DF
Sterile filtration
Fill and finish
  • IVT-mRNA

    • Two capping methods: enzymatic and co-transcriptional capping methods (license in)
    • Robust manufacturing process for different mRNA template
    • IVT scale: mg-g
    • mRNA Purity: >90%
  • mRNA-LNP

    • Universality: suitable for different LNP formulations
    • Encapsulation efficiency: 90%~99.7%
    • Excellent CQA characteristics

mRNA Service

IND
Phase I
Phase II
Phase III
BLA
Pre-Clinical
Commercial
Pro Grade
GMP Grade
GMP Grade
BLA CMC
GMP Grade

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