Innovative SMABody Bispecific Antibody Discovery Services

Discover the Future of Therapeutic Antibodies

SMABody Bispecific Antibody Discovery Services

Bispecific antibodies have become increasingly of interest for therapeutic applications. While natural antibodies are monospecific, bispecific antibodies recognize two different epitopes either on the same or on different antigens. The 'zoo' of bispecific antibodies is populated by many different species, comprising around 100 different formats, including various engineering of antibody fragments in symmetric or asymmetric manner.

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Benefits of Bispecific Antibody

• Novel
  MOA

  
  Superior Potency through
  Novel MOA

• Improved
  Safety

  
  Low off-target binding reduces
  side effects

• Controlling
  Price

  
  Develop only 1 molecule and save 1/2 of investment in comparison with combination therapy

Concerns in Developing Bispecific Antibody

ProBio's SMABody Bispecific Antibody

ProBio SMABody(Single-domain antibody fused to monoclonal Ab) platform naturally combine the single domain antibody and the monoclonal antibody to make a bispecific antibody in symmetric format with good biological efficacy and good developability.

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  Single Domain Antibody

Service Highlights

• • CLD titer>2g/L
  • Yield>60%
  • One step protein A purity>95%
  • Solubility>25mg/ml
  • Stability>95% after 5 time freeze-thaw
  • PK half life 2-3 weeks
  • Low immunogenicity risk
  • 3-5 month for SMABody™ screening & evaluation
  • 10 month for preclinical development
    • 1 plasmid system for CLD
    • No additional purification
    • No post-production process
• 
• • Ideal for dual targeting MOA
  • Flexibility to modulate dual target effect to achieve best potency
  • Possibility on ADCC/CDC enhancement
  • Uniqueness of sdAb to target to “hidden” epitope, such as GPCR
  • sdAb discovery or sdAb lead ready for use
  • No license Fee

Related service：single domain antibody discovery service

SMABody Collaboration Opportunities

SMABody Bispecific Antibody Platform is available for R&D service and co-development model.

Talk to our customer service representatives for collaboration opportunities.

Please download service quotation form and fill it before sending to us.